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Sickle Cell Anemia: "Sickle-cell disease is an inherited disorder resulting from an abnormality in the structure of a protein in the red blood cell called hemoglobin. It represents a spectrum of disorders ranging from the full-blown form, sickle-cell anemia, to the carrier state called sickle-cell trait or simply sickle trait." The Cambridge Historical Dictionary of Disease, 2003.
Heart: "The heart is a powerful organ about the size of a clenched fist. Located just to the left of centre in between the lungs, it operates as two coordinated pumps that send blood around the body." The Human Body Book: An Illustrated Guide to Its Structure, Function and Disorders, 2009.
See Part IV: Maintenance of the Body > Heart > Blood Flow through the Heart > Cardiac Conduction (Electrocardiogram)